Below are a list of mutagen mechanism descriptions (a-e)and a list of mutagen names (1-5).On the blank line following each mutagen,write the letter(s)of all descriptions that apply to that type of mutagen.Note that each statement may be used more than once and each type of mutation may have more than one correct statement.
a)Single-nucleotide insertions or deletions resulting in frameshift mutations if the mutation occurred in the coding region.The mutagen is a flat planar molecule that slips between stacked nitrogen bases.
b)Causes transitions (usually GC to AT)by adding an alkyl group to a base (usuallyG),thus altering its pairing properties.
c)Causes AT to GC transitions by acting as a base analogue for adenine.It is unstable and readily undergoes tautomeric shifts.Its imino form pairs with C rather than G.
d)Causes GC to TA transversions.Creates an apurinic site by breaking the base-sugar bonds.In order to correct the mutation,the SOS repair system preferentially adds an A opposite to G.
e)Makes pyrimidine dimers by making a bond between adjacent pyrimidines,thus interfering with the normal base pairing between the complementary DNA strands.
1)2-aminopurine __________
2)UV light __________
3)acridine orange __________
4)aflatoxin __________
5)ethylmethanesulfonate (EMS)__________
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