Deterioration of the pathway from the substantia nigra to the striatum is often found in cases of
A) Korsakoff's syndrome.
B) Parkinson's disease.
C) autism.
D) Alzheimer's disease.
E) multiple sclerosis.

Question

Quizplus · Accepted Answer

Parkinson's disease is characterized by the degeneration of dopaminergic neurons in the substantia nigra, leading to a decreased production of dopamine and subsequent deterioration of the pathway connecting the substantia nigra to the striatum. Korsakoff's syndrome is primarily associated with thiamine deficiency and damage to the mammillary bodies, while autism is thought to involve alterations in neural connectivity and synaptic communication rather than degeneration of specific pathways. Alzheimer's disease is characterized by the accumulation of beta-amyloid plaques and neurofibrillary tangles, and the involvement of different brain regions, whereas multiple sclerosis involves demyelination of neural pathways, but not specifically the pathway from the substantia nigra to the striatum.

Deterioration of the Pathway from the Substantia Nigra to the Striatum