A patient with a history of heart failure has been diagnosed with hypothyroidism. The drug interaction with glycosides and thyroid replacement therapy will most likely require which change in therapy?

Question

Quizplus · Accepted Answer

Hypothyroidism can decrease the sensitivity of the heart to digoxin, so when thyroid replacement therapy is initiated, the metabolism and sensitivity to digoxin may increase, necessitating a gradual increase in the glycoside dosage to maintain therapeutic effects.

A Patient with a History of Heart Failure Has Been