In functional brain-imaging studies of Tourette patients who are suppressing their tics, abnormal activity has been consistently observed in the caudate and

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Functional brain-imaging studies of Tourette patients who are suppressing their tics have consistently shown abnormal activity in the caudate and prefrontal cortex. This suggests a dysfunction in the cortico-striato-thalamo-cortical circuit, which is responsible for voluntary control of movements. The cerebellum, primary and association motor cortex, and dorsal horn are not consistently implicated in tic suppression in Tourette's syndrome.

In Functional Brain-Imaging Studies of Tourette Patients Who Are Suppressing