Which gene has been implicated in both early-onset Alzheimer's disease and Down syndrome?
A)APOE
B)APP
C)PS1
D)PS2

Question

Quizplus · Accepted Answer

The APP (amyloid precursor protein) gene has been implicated in both early-onset Alzheimer's disease and Down syndrome. The APP gene is located on chromosome 21, and individuals with Down syndrome have an extra copy of chromosome 21, leading to overexpression of APP and an increased risk for Alzheimer's disease. Mutations in the APP gene have also been identified in people with early-onset Alzheimer's disease.

Which Gene Has Been Implicated in Both Early-Onset Alzheimer's Disease