Give the best description for the regioselectivity and stereospecificity in the hydroboration-oxidation of an alkene.
A) Markovnikov orientation with syn-addition
B) Markovnikov orientation with anti-addition
C) Anti-Markovnikov orientation with syn-addition
D) Anti-Markovnikov orientation with anti-addition
E) Markovnikov orientation with both syn- and anti-addition

Question

Quizplus · Accepted Answer

In the hydroboration-oxidation of an alkene, the regioselectivity is anti-Markovnikov orientation, which means that the boron adds to the less substituted carbon, and the hydrogen adds to the more substituted carbon. The stereospecificity is syn-addition, meaning that the boron and hydrogen add to the same face of the alkene. Therefore, the best choice is C, which corresponds to anti-Markovnikov orientation with syn-addition.

Give the Best Description for the Regioselectivity and Stereospecificity in the Hydroboration-Oxidation