The following synthesis is not likely to work. Which of the following explains why? A) Lithium cannot react with aryl halides to form organolithium compounds. B) CH₃CH₂Br does not do cross coupling in Corey-Posner/Whitesides-House reactions. C) The cuprate formed would react with the ketone. D) The organolithium formed would react with the ketone.

Question

Quizplus · Accepted Answer

The synthesis involves using lithium and an aryl halide to form an organolithium compound, which would then react with a ketone to form a new compound. However, organolithium compounds are highly reactive and can undergo a variety of side reactions. In this case, the organolithium compound formed would likely react with the ketone to form a different product, rather than the desired one. Therefore, the synthesis is not likely to work.

The Following Synthesis Is Not Likely to Work