Who is more affected by X-linked inherited disorders?

Question

Quizplus · Accepted Answer

X-linked disorders are caused by mutations on genes found on the X chromosome. Males only have one X chromosome (inherited from their mother), while females have two X chromosomes (one from each parent). Therefore, if a male inherits a mutation on his X chromosome, he will be affected by the disorder because he has no other copy to compensate for the mutation. In contrast, females can be carriers of X-linked disorders (meaning they have one mutated X chromosome and one normal X chromosome) but are less likely to be affected by the disorder unless both X chromosomes have the mutation. Children under one year of age and adults with mutations may also be affected by X-linked disorders, but the question is asking specifically about inherited cases.

Who Is More Affected by X-Linked Inherited Disorders