In Alzheimer patients, neural damage from amyloid plaques, may cause neuronal damage by
A) breaking down the blood-brain barrier.
B) inducing glutamate toxicity.
C) increasing calcium influx.
D) both (a) and (b) above.
E) both (b) and (c) above.

Question

Quizplus · Accepted Answer

Amyloid plaques in Alzheimer's disease have been shown to induce glutamate toxicity in neurons, leading to excessive calcium influx and subsequent neuronal damage. This neuronal damage is the hallmark characteristic of Alzheimer's disease. Amyloid plaques have not been implicated in breaking down the blood-brain barrier.

In Alzheimer Patients, Neural Damage from Amyloid Plaques, May Cause