Endogenous pyrogens released by macrophages causes the hypothalamus to elevate body temperature during times of infection.

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Quizplus · Accepted Answer

This statement is true. Endogenous pyrogens, such as interleukin-1 (IL-1) and tumor necrosis factor alpha (TNF-alpha), are released by macrophages in response to infection. They act on the hypothalamus to stimulate the production of prostaglandins, which increase the body's set point for temperature and cause fever. This is an important immune response to help the body fight off infection.

Endogenous Pyrogens Released by Macrophages Causes the Hypothalamus to Elevate