Naltrexone is an antagonist at the mu opioid receptor.What is the hybridization state and geometry of the nitrogen atom in naltrexone?

Question

Quizplus · Accepted Answer

The nitrogen atom in naltrexone is connected to three other atoms (two carbons and one oxygen), which suggests sp2 hybridization. However, it also has one lone pair of electrons, which would require a p orbital to be involved in the hybridization. Therefore, the nitrogen atom in naltrexone is sp2³ hybridized and has a trigonal pyramidal geometry.

Naltrexone Is an Antagonist at the Mu Opioid Receptor