The body's response to IgE-mediated allergic reaction is the same no matter where the site of allergen contact is.
The body's response to IgE-mediated allergic reaction is different,depending where the site of allergen contact is.

Question

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The body's response may vary depending on the site of allergen contact. For example, a person with a peanut allergy may experience hives and anaphylaxis if they ingest peanuts, but may experience only a localized rash if they come into contact with peanuts on their skin.

The Body's Response to IgE-Mediated Allergic Reaction Is the Same