Which of the following sequence of events best explains the formation of carbamate in the mechanism of carbamoyl phosphate synthetase? A)Bicarbonate and ATP form carboxyphosphate, then NH₃ performs a nucleophilic attack on carboxyphosphate to form carbamate B)Bicarbonateis attacked by NH₃ to produce carbamate with ATP hydrolysis occurring solely to drive the reaction to completion C)Bicarbonate reacts with ATP forming carboxy adenylate and pyrophosphate, then NH₃ performs a nucleophilic attack on carboxy adenylate to form carbamate D)NH₃ reacts with ATP, which then reacts with bicarbonate followed by loss of phosphate to produce carbamate E)none of the above

Question

Quizplus · Accepted Answer

Bicarbonate reacts with ATP to form carboxyphosphate, which is then attacked by NH3 to form carbamate.

Which of the Following Sequence of Events Best Explains the Formation