The following molecule is an irreversible inhibitor of which enzyme of nucleotide metabolism?
A)ribonucleotide reductase
B)thymidylate synthase
C)thymidine kinase
D)dCMP deaminase
E)CTP synthetase

Question

The following molecule is an irreversible inhibitor of which enzyme of nucleotide metabolism? 
A)ribonucleotide reductase 
B)thymidylate synthase 
C)thymidine kinase 
D)dCMP deaminase 
E)CTP synthetase

Quizplus · Accepted Answer

The molecule shown in the image is a structural analogue of dUMP, which is the substrate for thymidylate synthase. Since this inhibitor has a covalent bond with the enzyme's active site, it blocks the catalytic activity of thymidylate synthase irreversibly, preventing the synthesis of dTMP from dUMP. Therefore, the correct option is B - thymidylate synthase.

The Following Molecule Is an Irreversible Inhibitor of Which Enzyme