Which of the following was evidence that DNA polymerase I was not responsible for the bulk of DNA synthesis in vivo? A)the requirement for an RNA primer B)the presence of both polymerase and exonuclease activity in the same enzyme C)the number of enzyme copies in each cell far exceeded the number of replication forks D)the requirement for Mg²⁺ E)none of the above

Question

Quizplus · Accepted Answer

The number of enzyme copies of DNA polymerase I in each cell far exceeded the number of replication forks, suggesting that it was not the primary enzyme responsible for DNA synthesis during replication. This discrepancy indicated that another polymerase must be responsible for the bulk of DNA synthesis in vivo.

Which of the Following Was Evidence That DNA Polymerase I