Why Are Water-Soluble Chemicals Sometimes Safer for Humans but Not

Why are water-soluble chemicals sometimes safer for humans but not for the environment?

A) They have a low persistence in the environment.
B) Humans can excrete water-soluble chemicals in their urine,but environments are "stuck" with them.
C) Water-soluble chemicals are stored in human fat,so they cannot harm organs.
D) Water-soluble chemicals have a greater tendency to be biomagnified.
E) Water-soluble chemicals have a greater tendency to be bioaccumulated.