Which of the labeled hydrogen atoms in the following structure is the most acidic?
A)1
B)2
C)3
D)4

Question

Which of the labeled hydrogen atoms in the following structure is the most acidic? 
A)1 
B)2 
C)3 
D)4

Quizplus · Accepted Answer

The most acidic hydrogen in a molecule is the one that is most likely to dissociate (lose a proton) in solution. The nitrogen in the amide group adjacent to the hydrogen atom in option C stabilizes the negative charge created by the loss of the proton, making it more likely to dissociate and thus more acidic than the other labeled hydrogen atoms in the molecule.

Which of the Labeled Hydrogen Atoms in the Following Structure