Identify the first step in the mechanism for the vitamin KH 2 -dependent carboxylation of glutamate.

The first step in the mechanism for the vitamin K-dependent carboxylation of glutamate involves the vitamin losing a proton from a phenolic OH group. This step is crucial for activating the vitamin K and preparing it for its role in the carboxylation process.

Identify the first step in the mechanism for the vitamin KH 2 -dependent carboxylation of glutamate.

The first step in the mechanism for the vitamin K-dependent carboxylation of glutamate involves the vitamin losing a proton from a phenolic OH group. This step is crucial for activating the vitamin K and preparing it for its role in the carboxylation process.

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Identify the First Step in the Mechanism for the Vitamin

Question 64

Multiple Choice

Identify the first step in the mechanism for the vitamin KH₂-dependent carboxylation of glutamate.

A) The vitamin K base removes a proton from the gamma-carbon of the gluatamate.
B) The vitamin loses a proton from a phenolic OH group.
C) The dioxetane collapses to form a vitamin K base.
D) The base attacks molecular oxygen.
E) The glutamate carbanion attacks carbon dioxide.

Correct Answer: