Which of the following reaction sequences best describes the formation of the nucleic acid in the biosynthesis of DNA?
A)nucleophilic attack of a 5'-OH group of one nucleotide on the β-phosphorus of another
B)nucleophilic attack of a 5'-OH group of one nucleotide on the α-phosphorus of another
C)nucleophilic attack of a 3'-OH group of a nucleotide on the γ-phosphorus of another
D)nucleophilic attack of a 3'-OH group of one nucleotide on the β-phosphorus of another
E)nucleophilic attack of a 3'-OH group of one nucleotide on the α-phosphorus of another

Question

Quizplus · Accepted Answer

In the biosynthesis of DNA, the formation of the nucleic acid backbone involves a nucleophilic attack by the 3'-OH group of one nucleotide on the α-phosphorus of another nucleotide's triphosphate group, leading to the formation of a phosphodiester bond and the release of pyrophosphate. This reaction is catalyzed by DNA polymerases.

Which of the Following Reaction Sequences Best Describes the Formation