Which statement about N-linked glycosylation is correct?
A)N-linked oligosaccharides are attached to proteins one sugar at the time in the endoplasmic reticulum.
B)N-linked sugars are attached to proteins as a 14 residue oligosaccharide during translation in the endoplasmic reticulum.
C)N-linked sugars are attached to proteins as a 14 residue oligosaccharide during translation in the cytoplasm.
D)N-linked sugars are attached to proteins as a 14 residue oligosaccharide after translation in the Golgi apparatus.
E)N-linked oligosaccharides are attached to proteins one sugar at the time in the Golgi apparatus.

Question

Quizplus · Accepted Answer

N-linked sugars are attached to proteins as a 14 residue oligosaccharide during translation in the endoplasmic reticulum. The oligosaccharide is covalently attached to the protein at a specific Asn residue in the sequon Asn-X-Ser/Thr (where X can be any amino acid except Pro). This process is catalyzed by an oligosaccharyltransferase enzyme complex. The N-linked oligosaccharide then undergoes further modification and maturation in the Golgi apparatus.

Which Statement About N-Linked Glycosylation Is Correct