Consider a hypothetical hemoglobin-like molecule with a Hill coefficient (constant)of 1 and the same p₅₀ value as normal hemoglobin.Choose the statement below that best describes the two proteins. A)There is a cooperative interaction between oxygen-binding sites in both the hypothetical and normal hemoglobins. B)The hypothetical hemoglobin has a greater oxygen affinity than normal hemoglobin. C)The oxygen binding curve for the hypothetical hemoglobin is hyperbolic,and the curve for normal hemoglobin is sigmoidal. D)The two hemoglobins would be able to deliver about the same amount of oxygen to the tissues. E)At pO₂ less than p₅₀,normal hemoglobin has a greater Y_O2 value.

Question

Quizplus · Accepted Answer

The Hill coefficient is a measure of cooperativity in binding, with a value of 1 indicating no cooperativity. Therefore, the hypothetical hemoglobin does not exhibit cooperative binding. Both hemoglobins have the same p₅₀ value, indicating the same oxygen affinity. However, the hypothetical hemoglobin has a hyperbolic oxygen binding curve since it does not exhibit cooperativity, while normal hemoglobin has a sigmoidal curve due to cooperative binding. Therefore, statement C is the best choice. Statements A, B, D, and E are all false based on the information given.

Consider a Hypothetical Hemoglobin-Like Molecule with a Hill Coefficient (Constant)of