In sickle-cell anemia,the negatively charged glutamic acid residue is replaced by the neutral amino acid ____________.
A)tyrosine
B)lysine
C)valine
D)adenosine
E)glycine

Question

Quizplus · Accepted Answer

In sickle-cell anemia, the negatively charged glutamic acid residue at position 6 of the beta-globin chain is replaced by the neutral amino acid valine due to a point mutation in the HBB gene on chromosome 11. This substitution of valine for glutamic acid disrupts the structure of the hemoglobin molecule, resulting in the characteristic sickle shape of the red blood cells and leading to various complications.

In Sickle-Cell Anemia,the Negatively Charged Glutamic Acid Residue Is Replaced