Which statement about antigen-binding sites in antibodies is false?
A)An antigen-binding site on an IgG is formed by the amino-terminal ~110 amino acids of a light chain and the amino terminal ~110 amino acids of a heavy chain.
B)An antigen-binding site on an IgG is formed by the variable region of a light chain and the variable region of a heavy chain.
C)The antigen-binding site is composed of two Ig folds.
D)Antigen-binding specificity is determined by the sequences of the hypervariable sequences in both the light chain and the heavy chain.
E)Antigen binding specificity is determined exclusively by the sequences in the carboxy-terminal ~110 amino acids in the light chain and the heavy chain.

Question

Quizplus · Accepted Answer

This statement is false because antigen binding specificity is determined by the sequences of the hypervariable regions, which are located within the variable region of both the light chain and the heavy chain. The carboxy-terminal ~110 amino acids are not involved in antigen binding.

Which Statement About Antigen-Binding Sites in Antibodies Is False