Drug resistance is frequently traced to
(I)the MDR transporter.
(II)overexpression of P-glycoprotein.
(III)increased number of specific ABC transporters.
(IV)the evolution of selectivity filters.

Question

Quizplus · Accepted Answer

Drug resistance is frequently traced to the MDR transporter, which is involved in exporting drugs out of cells. Overexpression of P-glycoprotein, which is an MDR transporter, can also lead to drug resistance. The increased number of specific ABC transporters is another mechanism that can contribute to drug resistance. The evolution of selectivity filters, however, is not a commonly identified mechanism behind drug resistance.

Drug Resistance Is Frequently Traced to