Which of the following is (are)the result of insulin binding to its receptor?
(I)MAPK activation,which regulates gene expression via Fos,Jun and Myc.
(II)PI3K activation leading to an increase in glucose transport.
(III)High affinity binding of SH2 domains to phosphorylated tyrosines.
(IV)Autophosphorylation resulting in activation of tyrosine kinase.
A)II,III,IV
B)I,II,III,IV
C)II,III
D)I,II
E)III only

Question

Quizplus · Accepted Answer

Insulin binding to its receptor leads to several downstream effects: (I) MAPK pathway activation, which indeed regulates gene expression through factors like Fos, Jun, and Myc; (II) PI3K activation, which is crucial for the translocation of glucose transporters to the cell membrane, thereby increasing glucose uptake; (III) The insulin receptor, upon activation, undergoes autophosphorylation on tyrosine residues, creating high-affinity binding sites for SH2 domain-containing proteins; (IV) This autophosphorylation is a key step in activating the receptor's intrinsic tyrosine kinase activity, which is essential for most downstream signaling events initiated by insulin.

Which of the Following Is (Are)the Result of Insulin Binding