Which of the following are activated either directly or indirectly by a heterotrimeric G protein subunit?
(I)phospholipase C
(II)Herceptin ®
(III)calmodulin (CaM)sensitive kinase
(IV)MAPK
A)I,II,III,IV
B)I,II
C)I,III
D)II,III,IV
E)I,II,IV

Question

Quizplus · Accepted Answer

Phospholipase C is directly activated by a heterotrimeric G protein subunit through the alpha subunit. Calmodulin-sensitive kinase is indirectly activated by a heterotrimeric G protein subunit through activation of phospholipase C and the subsequent increase in intracellular calcium, which activates calmodulin. Herceptin® and MAPK are not activated by heterotrimeric G proteins.

Which of the Following Are Activated Either Directly or Indirectly