Which of the following correctly states an essential step in the function of heterotrimeric G protein function?
A)A cascade of events must occur that ultimately activate protein kinase C.
B)Binding of a hormone to a receptor must signal the exchange of GDP for GTP.
C)Binding of GTP to the receptor protein must induce a change in conformation of the receptor.
D)Binding of cAMP to the α subunit of the G protein must initiate translocation of the subunit.
E)All of the above are correct.

Question

Quizplus · Accepted Answer

Heterotrimeric G protein function involves the binding of a hormone to a receptor, which signals the exchange of GDP for GTP on the α subunit of the G protein. This results in a conformational change that allows the activated α subunit to bind and regulate downstream effector proteins. The other options listed are not essential steps in the function of heterotrimeric G proteins.

Which of the Following Correctly States an Essential Step in the Function