The Reaction Catalyzed by the Enzyme Aldolase Has A $\Delta$ G˚' ≈ +23 KJ/mol

The reaction catalyzed by the enzyme aldolase has a $\Delta$ G˚' ≈ +23 kJ/mol.In muscle cells,the reaction proceeds in this same,forward direction.How can this occur?

A) This $\Delta$ G˚' means it is thermodynamically favored.
B) The enzyme changes the ∆G of the reaction in cells to something favorable.
C) The concentration of reactant(s) must be significantly greater than product(s) in cells.
D) The concentration of product(s) must be significantly greater than reactant(s) in cells.
E) none of the above