Rotenone and amytal
(I)inhibition can be restored by addition of succinate
(II)inhibition can be restored by addition of cytochrome c.
(III)blocks consumption of oxygen.
(IV)blocks transfer of electrons from CoQ to Complex III.
A)I,II,III,IV
B)I,II,III
C)II,III,IV
D)III only
E)IV only

Question

Quizplus · Accepted Answer

Rotenone and amytal are inhibitors of Complex I in the electron transport chain. 
(I) The addition of succinate bypasses Complex I and donates electrons downstream to Complex II, restoring electron flow and ATP production. 
(II) Cytochrome c is not involved in Complex I, so its addition would not restore function.
(III) Rotenone and amytal block the transfer of electrons in Complex I, leading to a buildup of electron carriers downstream and a decrease in oxygen consumption. 
(IV) Rotenone and amytal specifically block the transfer of electrons from CoQ to Complex III, leading to a buildup of CoQ and a decrease in electron flow downstream.

Rotenone and Amytal (I)inhibition Can Be Restored by Addition of Succinate