A poison that prevents the transfer of electrons from the last [Fe-S] cluster of Complex I to coenzyme Q is added to a suspension of actively respiring mitochondria.Which of the following will be observed?

Question

Quizplus · Accepted Answer

DC) ATP production would be reduced due to a decrease in the number of protons pumped out of the mitochondrial matrix. This is because the blockage of electron transfer from Complex I to coenzyme Q would reduce the proton gradient necessary for ATP synthesis via oxidative phosphorylation.D) ATP production would be halted completely due to the block in electron transport through the electron transport chain. This statement is partially correct in the context that the blockage at Complex I would severely impair the electron transport chain's function, but it might not halt ATP production completely as electrons can still enter the electron transport chain via Complex II, albeit at a reduced efficiency.

A Poison That Prevents the Transfer of Electrons from the Last