Matching
Choose the correct answer from the list.Not all the answers will be used.

-Purines are degraded to ______.
A) fumarate
B) NADPH
C) salvage
D) uric acid
E) oxidation
F) XMP
G) iron
H) allopurinol
I) IMP
J) Oxidation
K) therapeutic
L) suicide
M) molybdenum
N) FADH
O) Malonyl-CoA
P) reduction
Q) antifolate

Question

Matching
Choose the correct answer from the list.Not all the answers will be used.

-Purines are degraded to ______.
A) fumarate
B) NADPH
C) salvage
D) uric acid
E) oxidation
F) XMP
G) iron
H) allopurinol
I) IMP
J) Oxidation
K) therapeutic
L) suicide
M) molybdenum
N) FADH
O) Malonyl-CoA
P) reduction
Q) antifolate

Quizplus · Accepted Answer

Purines are degraded to uric acid, which is excreted in urine in mammals.

Answer: H
 Allopurinol is a therapeutic drug used to inhibit the enzyme xanthine oxidase, which catalyzes the final step of purine degradation into uric acid. By inhibiting this enzyme, allopurinol reduces the production of uric acid and can be used to treat conditions such as gout.

Answer: L
 Suicide inhibition is a mechanism by which a substrate or analog irreversibly binds to and inhibits an enzyme. Allopurinol is an example of a suicide inhibitor, since it forms a covalent bond with xanthine oxidase and permanently inactivates the enzyme.

Matching Choose the Correct Answer from the List.Not All the Answers