The symptoms of Lesch-Nyhan syndrome are caused by a deficiency of which of the following enzymes?

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Lesch-Nyhan syndrome is caused by a deficiency of HGPRT (hypoxanthine-guanine phosphoribosyltransferase) enzyme which normally converts hypoxanthine and guanine into nucleotides for DNA and RNA synthesis. The lack of this enzyme leads to the accumulation of uric acid and other purine metabolites, which causes the characteristic symptoms of the disease including severe neurological and behavioral abnormalities, self-injurious behavior, gout, and kidney stones.

The Symptoms of Lesch-Nyhan Syndrome Are Caused by a Deficiency