Which best describes the synthesis of purine nucleotides?
A)The basic ring structure,orotate,is synthesized and then linked to PRPP.This is then modified to produce either GMP or AMP.
B)The basic ring structure,inosine,is synthesized and then linked to PRPP.This is then modified to produce either GMP or AMP.
C)The basic ring structure,orotate,is synthesized stepwise on PRPP.This is then modified to produce either GMP or AMP.
D)The basic ring structure,inosine,is synthesized stepwise on PRPP.This is then modified to produce either GMP or AMP.
E)The basic ring structure,orotate,is synthesized and then linked to PRPP.This is then modified to produce either UMP or CMP.

Question

Quizplus · Accepted Answer

The synthesis of purine nucleotides involves the stepwise construction of the inosine (purine) ring structure directly on the ribose phosphate backbone provided by 5-phosphoribosyl-1-pyrophosphate (PRPP). This process eventually leads to the production of inosine monophosphate (IMP), which can then be further modified to produce either guanosine monophosphate (GMP) or adenosine monophosphate (AMP).

Which Best Describes the Synthesis of Purine Nucleotides