The last step in purine degradation (I)generates hydrogen peroxide as a byproduct. (II)utilizes molecular oxygen. (III)is inhibited by methotrexate. (IV)requires NAD⁺.

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Quizplus · Accepted Answer

The last step in purine degradation generates uric acid, during which hydrogen peroxide (I) is produced as a byproduct, and molecular oxygen (II) is utilized. Methotrexate inhibits dihydrofolate reductase, which is involved in nucleotide synthesis rather than purine degradation, and there is no known compound or requirement as NAD⁺ in purine degradation.

The Last Step in Purine Degradation