If a circular DNA containing no supercoils is incubated with ethidium bromide
A)the number of twists will increase,positive supercoils will develop,and the linking number will remain the same.
B)the number of twists will decrease,positive supercoils will develop,and the linking number will remain the same.
C)the number of twists will increase,negative supercoils will develop,and the linking number will remain the same.
D)the number of twists will decrease,negative supercoils will develop,and the linking number will remain the same.
E)the linking number will be altered,and both the writhing number and twist will adjust accordingly.

Question

Quizplus · Accepted Answer

Ethidium bromide intercalates between base pairs of DNA, causing it to unwind and the number of twists to decrease. Negative supercoils will also develop to compensate for the induced unwinding, while the linking number will remain the same.

If a Circular DNA Containing No Supercoils Is Incubated with Ethidium