Which of the following patients is most at risk for theophylline toxicity due to decreased biotransformation ability?

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Biotransformation occurs when enzymes detoxify (remove toxic qualities),degrade (break down),and remove biologically active chemicals.Most biotransformation occurs within the liver,although the lungs,kidneys,blood,and intestines also metabolize medications.The liver is especially important because its specialized structure oxidizes and transforms many toxic substances.The liver degrades many harmful chemicals before they become distributed to the tissues.If a decrease in liver function occurs,such as with aging or liver disease,the body slowly eliminates a medication,resulting in a buildup of the medication.When organs that metabolize medications do not function correctly,patients are at risk for medication toxicity.

Which of the Following Patients Is Most at Risk for Theophylline