Brain imaging studies of the Big Five personality traits have found that conscientiousness is associated with a large region of the frontal cortex called the middle frontal gyrus, which is known to be involved in planning, working memory, and self-regulation.

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This statement is true. Studies have shown that the trait of conscientiousness is associated with increased activation and gray matter volume in the middle frontal gyrus.

Brain Imaging Studies of the Big Five Personality Traits Have