According to the Focus on Neuroscience box: "The Neuroscience of Personality: Brain Structures and the Big Five," researchers have found that conscientiousness is associated with a large region of the frontal cortex called the:

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Researchers have found that conscientiousness is associated with a large region of the frontal cortex called the middle frontal gyrus, which is involved in high-level cognitive functions such as planning, problem-solving, and decision-making.

According to the Focus on Neuroscience Box: "The Neuroscience of Personality