A 45-Year-Old Female Complains of Feeling Extremely Anxious, Fatigued, and Has

A 45-year-old female complains of feeling extremely anxious, fatigued, and has a loss of enjoyment of previously engaging activities. She has a difficult time arising from bed in the morning to go to work. She has lost her appetite, cannot sleep, and has trouble "thinking straight." On physical examination, there are no significant findings. These signs and symptoms are characteristic of:

A) The presence of a malignancy
B) Clinical depression
C) Hypothyroidism
D) Adrenal insufficiency