A 45-Year-Old Female Complains of Recent Weight Gain,amenorrhea for 3

A 45-year-old female complains of recent weight gain,amenorrhea for 3 months,and bruising.No current medications.Medical and surgical history positive for cholecystectomy at age 41.On review of systems,patient reveals hair growth on face,acne,and easy bruisability.Vital signs: afebrile,pulse 80,12 resps/min,BP 148/92.Physical examination shows abdominal obesity and striae over abdomen.Which of the following question is most helpful toward a differential diagnosis?

A) Have you used corticosteroids in the last month?
B) How much weight have you gained in the last 3 months?
C) Have you had any bleeding episodes,such as nosebleeds or gums bleeding?
D) Is cancer in the family history?