How do genetic/genomic issues influence individual variation of the response to a specific drug?

Question

Quizplus · Accepted Answer

Polymorphisms of genes encoding metabolizing enzymes can affect the metabolism of drugs in the body, leading to variations in response to drugs. Individuals with different alleles of the same gene may have different rates of drug metabolism, altering the drug's efficacy or toxicity.

Answer: C
 Single gene disorders that reduce the function of the liver or the kidneys can lead to altered metabolism and clearance of drugs, leading to variability in drug response. Patients with genetic conditions such as Gilbert's syndrome or cystic fibrosis may process drugs differently than those without the condition, leading to different responses.

Answer: D
 Genetic-based behavior problems that promote poor adherence to prescribed drug regimens can impact the effectiveness of the drug. For example, genetic variants associated with attention deficit hyperactivity disorder (ADHD) may lead to poor adherence to medication regimens for patients with ADHD, leading to variable drug response.

Therefore, the best choices are A and C.

How Do Genetic/genomic Issues Influence Individual Variation of the Response