Which common childhood disorder requires a genetic contribution and a significant environmental contribution to develop fully?

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Type 1 diabetes mellitus requires both a genetic contribution and a significant environmental contribution to develop fully. Genetic factors play a significant role in susceptibility to the disease, but it also requires an environmental trigger (such as a viral infection) to fully develop. Achondroplasia and von Willebrand disease both have a primarily genetic basis, while sickle cell disease is primarily caused by a genetic mutation but also has some environmental factors (such as exposure to high altitudes) that can exacerbate symptoms.

Which Common Childhood Disorder Requires a Genetic Contribution and a Significant