Which reproductive consequence is possible for a man who has a 13;15 Robertsonian translocation when his wife has a normal karyotype?

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Quizplus · Accepted Answer

A Robertsonian translocation involves the fusion of two acrocentric chromosomes, resulting in a single larger chromosome. If the translocated chromosome is involved in gamete formation, it can lead to either a balanced or unbalanced gamete. In the case of a 13;15 Robertsonian translocation, the individual can produce gametes with either a balanced translocation (carrying both chromosome 13 and 15 material) or an unbalanced translocation (missing some genetic material from one or both chromosomes). If the individual produces an unbalanced gamete, it can result in a child with trisomy 13 or 15. If the individual produces a balanced gamete, it may still result in a child with an unbalanced karyotype if they inherit the translocated chromosome. As the wife has a normal karyotype, there are no increased risks for chromosomal abnormalities in her gametes.

Which Reproductive Consequence Is Possible for a Man Who Has