Which of the following is/are true about the relationship between chloride (Cl^-) and bicarbonate HCO₃^- in acid-base balance?
1) For each Cl^- ion excreted into the urine, the blood gains an HCO₃^- ion.
2) Blood Cl^- and HCO₃^- ion levels are reciprocally related.
3) People with chronically high CO₂ tend to have low blood Cl^- levels.
4) Activation of the NH₃ buffer system enhances Cl^- gain and HCO₃ loss.

Question

Quizplus · Accepted Answer

1) This statement is true because the kidney can exchange chloride ions for bicarbonate ions in the urine, which helps regulate blood pH.2) True, because in the body's effort to maintain acid-base balance, an increase in chloride can lead to a decrease in bicarbonate and vice versa, due to their roles in maintaining electrical neutrality.3) True, because high CO2 levels lead to increased production of bicarbonate (as part of the body's buffering system), which can result in lower chloride levels due to the reciprocal relationship between bicarbonate and chloride.

Which of the Following Is/are True About the Relationship Between