What is the most important factor contributing to the onset of pulmonary hypertension in the patient with COPD?

Question

Quizplus · Accepted Answer

Alveolar hypoxia, because of its potent pulmonary vasoconstrictive effect, is probably the most important factor contributing to pulmonary hypertension in patients with COPD. Sustained alveolar hypoxia causes pulmonary vasoconstriction and eventually medial hypertrophy, fibrosis of the intima, and narrowing of the lumen of the pulmonary blood vessels.

What Is the Most Important Factor Contributing to the Onset