Which of the following best describes a proper a dose-response assessment of a metered dose inhaler (MDI) bronchodilator?
A) Give 4 puffs one after the other, wait 1 min, repeat up to 16 puffs. The best dose is the highest dose given without side effects.
B) Give 4 puffs spaced 1 to 2 min apart; repeat up to 12 puffs with continued improvement. The best dose provides maximum subjective relief and the highest peak expiratory flow rate (PEFR) without side effects.
C) Give 12 puffs 1 min apart; repeat every 20 min until maximum relief of symptoms is achieved without side effects.
D) Give 2 puffs 1 to 2 min apart; repeat up to 6 puffs with continued improvement. The best dose provides maximum subjective relief and the highest PEFR without side effects.
Correct Answer:
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