To prevent an adverse rebound effect when withdrawing NO therapy, what should you do?
1) Reduce the NO to the lowest effective dose (ideally, less than 5 ppm).
2) Hyperoxygenate the patient just before discontinuing NO.
3) Ensure that the patient is hemodynamically stable.

Question

Quizplus · Accepted Answer

To prevent an adverse rebound effect when withdrawing NO therapy, it is necessary to: 
1) gradually reduce the NO to the lowest effective dose (ideally, less than 5 ppm) to prevent sudden increases in pulmonary vascular resistance and rebound pulmonary hypertension; 
2) hyperoxygenate the patient just before discontinuing NO to prevent hypoxia-induced vasoconstriction and rebound pulmonary hypertension; 
and 
3) ensure that the patient is hemodynamically stable to prevent exacerbation of any underlying cardiac condition. Therefore, all three options (1, 2, and 3) are necessary to prevent adverse rebound effects.

To Prevent an Adverse Rebound Effect When Withdrawing NO Therapy