Which of the Following Clinical Signs Indicate That a Patient

Which of the following clinical signs indicate that a patient is having a problem with retained secretions?
1) Copious amounts of sputum production
2) Labored breathing
3) Development of a fever
4) Increased inspiratory and expiratory crackles

A) 1 and 4 only
B) 1, 2, and 3 only
C) 3 and 4 only
D) 2, 3, and 4 only