A Nurse Explains to You That a Certain Neuromuscular Patient

A nurse explains to you that a certain neuromuscular patient cannot develop a good cough. Which of the following would you consider to manage this patient's clearance problem?
1) Combining manual chest compression with suctioning
2) Coordinating the coughing regimen with pain medication
3) Using the autogenic drainage method
4) Using mechanical insufflation-exsufflation

A) 1 and 4 only
B) 1, 2, and 3 only
C) 2 and 3 only
D) 1, 2, and 4 only