Administration of 80 mg propranolol given orally (PO)produces the same response as 1 mg intravenously (IV).The difference in dosage is explained by:

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When a drug is administered orally, it first passes through the liver before entering the systemic circulation. This is known as first-pass metabolism, which can lead to significant degradation or metabolism of the drug before it reaches its target site. This results in a lower bioavailability of the drug, meaning that less of the drug reaches its target site. Intravenous administration bypasses the liver and thus avoids first-pass metabolism, resulting in a higher bioavailability of the drug. In the case of propranolol, the difference in dosage between oral and intravenous administration is likely due to the first-pass effect.

Administration of 80 Mg Propranolol Given Orally (PO)produces the Same